Innovative Drug Discovery and Nanotechnology (Track)




The improvement of toxico-pharmacological properties of drugs by clathration with plant metabolites

Mikhail V. Khvostov
Laboratory of Pharmacological Research, N.N. Vorozhtsov Institute of Organic Chemistry Siberian Branch of RAS, 630090, Novosibirsk, Russia

Abstract:

In the modern pharmacology a problem of toxicity and low water solubility of drugs is solving by different ways. Our approach is based on clathration of known drugs with plant metabolites such as glycyrrhizic acid (a glycoside from licorice roots), arabinogalactan (a polysaccharide from Larix Sibirica), stevioside and rebaudioside (both are metabolites of Stevia rebaudiana). We have investigated numerous clatharates with different drugs (fluoxetin, phenibut, medazepam, warfarin, nifedipine, propranolol, amidaron, simvastatin, indometacin, diclofenac, ibuprofen, acetylsalicylic acid et al.) and demonstrate that the formation of clathrate improves bioavailability, increases water solubility (up to 50 times), reduces toxicity and often activates new properties of original drug. An effective dose could be significantly reduced (up to 100 times). Also, benefits of this method are abundance of plants mentioned above and simple synthesis. Thereby, we suggest inexpensive way to develop new low-toxic water soluble drugs.

Keywords: Clathration, low-toxic, water soluble drugs, plant metabolites.